Polyclonal–Monoclonal Distance
Tracking
clonal dominance
PMD is a geometric framework for quantifying clonal dominance in integration site analysis, positioning clonal populations along a continuum from maximal evenness to monoclonality.
Online analysis tool in development
The PMD clonal plane
About the research
The PMD framework combines observed clonal richness and dominant-clone abundance to support interpretable comparisons of clonal composition. The research also investigates fragmented dominance arising from multiple vector integrations.